We discuss the second part of the tissue processing journey: active tissue clearing using SmartClear. SmartClear active clearing is rapid, uniform, and nondestructive, ensuring maximum sample integrity.
We provide key insights into the first step of the tissue processing journey: tissue preservation using SHIELD. SHIELD is a tissue-gel hybridization method using polyfunctional, flexible epoxides to preserve tissue architecture, endogenous fluorescence, protein antigenicity, and nucleic acids.
Over 190 million people have now been infected with the novel coronavirus SARS-CoV-2 in the ongoing coronavirus disease (COVID-19) pandemic with a total number of deaths passing 4.1 million worldwide. Multiple organs are affected by COVID-19, however, the lungs are the main site of disease.
Recent advances in the tissue clearing field have unlocked the visualization of biology throughout whole organs. Tissue processing methods that render samples optically transparent can be combined with methods that enable the tissue-wide penetration of molecular probes such as antibodies.