Light Sheet Microscopy

Light Sheet Microscopy - Highlighted pipeline icon

SmartSPIM​

The SmartSPIM light sheet microscope provides unparalleled resolution and acquisition speed throughout intact tissue volumes, while its modular design allows you to upgrade and customize individual components.
Key highlights and features include:

  • Patented axial sweeping technology, which generates homogenous PSFz across field of view
  • Rapid volumetric acquisition (intact mouse brain hemisphere in <30 minutes)
  • Large imaging chamber and dual illumination, optimized for large (up to 40mm x 75mm) or multi-sample acquisition – easily image organoids, rat brains, entire juvenile mice, & everything in between
  • Focus compensation and tunable imaging parameters
  • Intuitive acquisition software with real-time tile correction
  • Objectives available for 1.63X through 22X magnification
Learn more about SmartSPIM
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MegaSPIM light sheet microscope

MegaSPIM

The MegaSPIM microscope is our newest light sheet imaging system. Utilizing the same powerful axial sweeping technology as SmartSPIM, MegaSPIM is optimized for imaging not only laterally large samples, but thin slices and arrays of small tissues as well. Unique highlights and features include:

  • Capacity for lateral sample sizes up to 200 mm x 200 mm –  easily image expanded tissues, large slabs, and arrays of organoids, slices, or whole rodent organs
  • Custom mounting solutions for a variety of sample types
  • High-throughput multicolor acquisition with dual cameras and independent focus correction
  • Post-processing tools to deskew and stitch your data into complete ready-to-analyze volumes
Learn more about MegaSPIM
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Recent publications citing LifeCanvas light sheet microscopy

Aging drives cerebrovascular network remodeling and functional changes in the mouse brain

Hannah C. Bennett, Qingguang Zhang, Yuan-ting Wu, Uree Chon, Patrick J. Drew, Yongsoo Kim

Journal:
bioRxiv
Publication Date:
Research Area:
Neurodegeneration, Vasculature
Tissue Species:
Mouse
Tissue Type:
Brain
Products Cited:
SmartSPIM
Loss of insulin signaling in astrocytes exacerbates Alzheimer-like phenotypes in a 5xFAD mouse model

Wenqiang Chen, Qian Huang, Ekaterina Katie Lazdon, Antonio Gomes, Marisa Wong, Emily Stephens, Tabitha Grace Royal, Dan Frenkel, Weikang Cai, C. Ronald Kahn

Journal:
PNAS
Publication Date:
Research Area:
Neurodegeneration, Metabolism
Tissue Species:
Mouse
Tissue Type:
Brain
Products Cited:
SHIELD, EasyIndex, Passive Clearing Kit, SmartSPIM, SmartAnalytics, CRO Services
Leveraging the Power of 3D Brain-Wide Imaging and Mapping Tools for Brain Injury Research in Murine Models

Mehwish Anwer, Jeffrey LeDue, Zefang Wang, Sarah Wang, Wai Hang Cheng, Mariia Burdyniuk, Honor Cheung, Jianjia Fan, Carlos Barron, Peter A. Cripton, Mark S. Cembrowski, Fabio Rossi, Timothy H. Murphy, Cheryl L. Wellington

Journal:
bioRxiv
Publication Date:
Research Area:
Brain Injury, Methods
Tissue Species:
Mouse
Tissue Type:
Brain
Products Cited:
SHIELD, EasyIndex, SmartBatch+, SmartSPIM, SmartAnalytics, CRO Services
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