Light Sheet Microscopy

SmartSPIM​

The SmartSPIM light sheet microscope provides unparalleled resolution and acquisition speed throughout intact tissue volumes, while its modular design allows you to upgrade and customize individual components.
Key highlights and features include:

  • Patented axial sweeping technology, which generates homogenous PSFz across field of view
  • Rapid volumetric acquisition (intact mouse brain hemisphere in <30 minutes)
  • Large imaging chamber and dual illumination, optimized for large (up to 40mm x 75mm) or multi-sample acquisition – easily image organoids, rat brains, entire juvenile mice, & everything in between
  • Focus compensation and tunable imaging parameters
  • Intuitive acquisition software with real-time tile correction
  • Objectives available for 1.63X through 22X magnification
Learn more about SmartSPIM
Contact an imaging specialist

MegaSPIM

The MegaSPIM microscope is our newest light sheet imaging system. Utilizing the same powerful axial sweeping technology as SmartSPIM, MegaSPIM is optimized for imaging not only laterally large samples, but thin slices and arrays of small tissues as well. Unique highlights and features include:

  • Capacity for lateral sample sizes up to 200 mm x 200 mm –  easily image expanded tissues, large slabs, and arrays of organoids, slices, or whole rodent organs
  • Custom mounting solutions for a variety of sample types
  • High-throughput multicolor acquisition with dual cameras and independent focus correction
  • Post-processing tools to deskew and stitch your data into complete ready-to-analyze volumes
Learn more about MegaSPIM
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Recent publications citing LifeCanvas light sheet microscopy

Astrocyte Gi-GPCR signaling corrects compulsive-like grooming and anxiety-related behaviors in Sapap3 knockout mice

Joselyn S. Soto, Chiranjivi Neupane, Muskan Kaur, Vijaya Pandey, James A. Wohlschlegel, Baljit S. Khakh

Journal:
Neuron
Publication Date:
Research Area:
cFos
Tissue Species:
Mouse
Products Cited:
SHIELD, SmartSPIM, SmartAnalytics, CRO Services
Adeno-associated virus delivered CXCL9 sensitizes glioblastoma to anti-PD-1 immune checkpoint blockade

Christina A. von Roemeling, Jeet A. Patel, Savannah L. Carpenter, Oleg Yegorov, Changlin Yang, Alisha Bhatia, Bently P. Doonan, Rylynn Russell, Vrunda S. Trivedi, Kelena Klippel, Daniel H. Ryu, Adam Grippin, Hunter S. Futch, Yong Ran, Lan B. Hoang-Minh, Frances L. Weidert, Todd E. Golde & Duane A. Mitchell

Journal:
Nature Communications
Publication Date:
Products Cited:
SmartBatch+, Passive Clearing Kit, SmartSPIM, CRO Services
Experience-dependent information routing through the basolateral amygdala shapes behavioral outcomes

Pantelis Antonoudiou, Bradly T. Stone, Phillip L.W. Colmers, Aidan Evans-Strong, Eric Teboul, Najah L. Walton, Grant L. Weiss, Jamie Maguire.

Journal:
Cell Reports
Publication Date:
Research Area:
Neural Circuits
Tissue Species:
Mouse
Tissue Type:
Brain
Products Cited:
SHIELD, SmartSPIM
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For technical support reach out to our dedicated customer support team at support@lifecanvastech.com.