While developing our next generation of electrophoretic tissue-processing devices, SmartBatch+, we have also been hard at work developing improvements to...
Our new Clear+ tissue clearing technique is the only method that delipidates and optically clears samples with no change in sample morphology and with minimal impact on structural integrity. Samples processed with our tissue clearing reagents retain mechanical strength, molecular stability, and native 3D structure.
An advance on our founder’s CLARITY method, this targeted delipidation approach is also dramatically faster: fully delipidate whole mouse brains in just one day with SmartBatch+ active clearing, or just one week with passive clearing. Clear+ can also delipidate larger samples like whole rat brains in ~4 days.
After clearing, leverage our active immunolabeling methods to rapidly and uniformly label whole organs from surface to core with significantly less antibody than passive techniques like iDISCO and CUBIC.
Start with the most versatile passive clearing method available: preserve, clear, and index-match your samples with our simple and reliable ready-made solutions, now featuring the Clear+ system.
Our reagents preserve fluorescent proteins, reduce autofluorescence, and optimally prepare samples for immunostaining, 3D imaging, and analysis. For significantly faster clearing speed and sample throughput, upgrade to electrophoretic clearing using SmartBatch+.
250 mL: Processes 8+ mouse brains or comparably sized samples. Includes: 250 mL SHIELD, 250 mL Clear+ Delipidation Buffer, and 250 mL EasyIndex.
500 mL: Processes 16+ mouse brains or comparably sized samples. Includes: 500 mL SHIELD, 500 mL Clear+ Delipidation Buffer, and 500 mL EasyIndex.
Wenqiang Chen, Qian Huang, Ekaterina Katie Lazdon, Antonio Gomes, Marisa Wong, Emily Stephens, Tabitha Grace Royal, Dan Frenkel, Weikang Cai, C. Ronald Kahn
Mehwish Anwer, Jeffrey LeDue, Zefang Wang, Sarah Wang, Wai Hang Cheng, Mariia Burdyniuk, Honor Cheung, Jianjia Fan, Carlos Barron, Peter A. Cripton, Mark S. Cembrowski, Fabio Rossi, Timothy H. Murphy, Cheryl L. Wellington
Kellie M. Williford, Anne Taylor, James R. Melchior, Hye Jean Yoon, Eryn Sale, Milen D. Negasi, Danielle N. Adank, Jordan A. Brown, Michelle N. Bedenbaugh, Joseph R. Luchsinger, Samuel W. Centanni, Sachin Patel, Erin S. Calipari, Richard B. Simerly, Danny G. Winder
While developing our next generation of electrophoretic tissue-processing devices, SmartBatch+, we have also been hard at work developing improvements to...
LifeCanvas tissue clearing is fast, reliable, and cost-effective, allowing uniform and simultaneous clearing for multiple samples.
Recent studies leverage LifeCanvas tissue clearing to closely investigate COVID-19's impact on lung tissues.
Delipidation is a critical step in many of the most popular tissue clearing methods, including CLARITY, iDISCO, SHIELD, and CUBIC.