β-amyloid disease plaques in magenta, astrocytes (GFAP) in cyan, 15X. Sample courtesy of Epp Lab, University of Calgary.
With uniform axial resolution across the whole sample, rapid volumetric imaging, and a custom-designed imaging chamber, our SmartSPIM light sheet imaging system provides the accuracy, speed, and flexibility you need to generate the highest quality data. Easily craft publication-ready analysis outputs with our SmartAnalytics workstation, tailor-made for SmartSPIM.
Left: The sample imaged without axial sweeping has high axial resolution only at the center of the FOV, while the sample imaged with sweeping has uniform axial resolution across the FOV.
Microglia (IBA-1, 647 nm) in cortex of a 7-month-old wild-type C57BL/6 male mouse from Taconic Biosciences, model #B6, 3.6X.
Tunable imaging parameters allow for high speed volumetric imaging while maintaining quality resolution. 20 fps acquisition allows imaging of a mouse brain hemisphere or comparably sized intact sample in <30 minutes (at 1.8 µm x 1.8 µm x 4 µm voxel size).
Streamlined for efficient data collection, SmartSPIM’s acquisition software has real-time tile correction and is simple to operate, making imaging large samples a breeze.
Custom-designed imaging chamber and sample holders can accommodate a variety of tissue sizes, from organoids to rat brains, and even entire juvenile mice! With no points of contact between tissue and mounting hardware, the user can mount many sample types and sizes in different orientations.