While developing our next generation of electrophoretic tissue-processing devices, SmartBatch+, we have also been hard at work developing improvements to...
Delipidation and refractive index (RI) -matching allow light to pass unhindered through the sample during microscopy. In effect, tissue clearing refers to the combined process of delipidation and optical clearing via index matching.
Delipidated tissues will appear translucent, while cleared and RI-matched tissues will appear transparent. Our preformulated EasyIndex solution prepares samples for sharp, informative volumetric imaging with light sheet microscopes like SmartSPIM.
The 500-mL EasyIndex bottle can be used for up to 12 whole mouse brains or similarly sized intact samples, or >200 1 mm-thick sections. We provide RI = 1.52 standard solutions with RI = 1.46 solution available on request.
EasyIndex is ideal for index-matching multiple tissue types, immunolabeled tissues, and specimens cleared with aqueous methods like SHIELD or CLARITY.
While developing our next generation of electrophoretic tissue-processing devices, SmartBatch+, we have also been hard at work developing improvements to...
LifeCanvas tissue clearing is fast, reliable, and cost-effective, allowing uniform and simultaneous clearing for multiple samples.
Recent studies leverage LifeCanvas tissue clearing to closely investigate COVID-19's impact on lung tissues.
Delipidation is a critical step in many of the most popular tissue clearing methods, including CLARITY, iDISCO, SHIELD, and CUBIC.