What makes the mouse model so popular for disease research? We discuss the benefits, complications, and ongoing improvements of murine...
Depositions of aberrant protein aggregates in the brain are recognized hallmarks of major neurodegenerative disorders like Alzheimer’s, Parkinson’s, and Huntington’s diseases. We can process and analyze samples for β-amyloid deposition (e.g. in Alzheimer’s), as well as for the accumulation of α-synuclein in Lewy Bodies (e.g. in Parkinson’s).
Localized damage to diseased brain parenchyma is often accompanied by a neuroinflammatory response, such as activation and recruitment of reactive glia (e.g. astrocytes, microglia). Our technologies can be used to assess these responses through mapping of astrocytes (GFAP+) and microglia (IBA1+).
Pictued above: Astrocytes marked by GFAP (magenta) cluster around β-amyloid plaques (cyan), in brain of 7-month-old homozygous ARTE10 male mouse from Taconic Biosciences, Alzheimer’s disease model #16347.
5xFAD mouse brain model of Alzheimer’s disease. Sample courtesy of Drs. David Elliott and Jonathan Epp, University of Calgary.
Upon receiving your samples, LifeCanvas technicians:
You send us: PFA-fixed brain samples from your disease model animals
We deliver:
What makes the mouse model so popular for disease research? We discuss the benefits, complications, and ongoing improvements of murine...
3D tissue clearing, labeling, imaging, and analysis tools provide critical spatial data for investigating neurological disorders.
Dr. Jonathan Epp's lab at the University of Calgary uses LifeCanvas tools to robustly characterize mouse models for Alzheimer's.
Prof. Li-Huei Tsai’s lab at MIT is focused on uncovering the cellular and circuit-level mechanisms that underlie Alzheimer’s disease, the...