Depositions of aberrant protein aggregates in the brain are recognized hallmarks of major neurodegenerative disorders like Alzheimer’s, Parkinson’s, and Huntington’s diseases. LifeCanvas offers researchers the opportunity to process and analyze samples for β-amyloid deposition (e.g. in Alzheimer’s) and for the accumulation of α-synuclein in Lewy Bodies (e.g. in Parkinson’s).
Localized damage to diseased brain parenchyma is often accompanied by a neuroinflammatory response, such as activation and recruitment of reactive glia (e.g. astrocytes, microglia). Our technologies can be used to assess these responses through mapping of astrocytes (GFAP+) and microglia (IBA1+) in animal disease models.
Upon receiving your samples for brain mapping, LifeCanvas technicians:
You send us: PFA-fixed brain samples from your disease model animals