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Whole organ preservation, active clearing and labeling, and light sheet imaging have solved many of the issues related to thin-section histology, including high consumption of time and resources, spotlight bias, and realignment errors. LifeCanvas’s tissue processing pipeline is the world’s only end-to-end solution for processing whole organs from preservation to analysis. Download the white paper to learn more!

Blog Posts

SDS monomers rupture cell membrane and form micelles to facilitate tissue clearing

How do detergents dissolve lipid membranes?

As explained in several of our blogs, delipidation is a critical step in the tissue clearing process. Some form of lipid removal is present in almost all of the most popular clearing techniques, including CLARITY, iDISCO, SHIELD, and CUBIC. In the case of SHIELD

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Schematic of Zsigmondy's ultramicroscope

Our favorite inventions for National Inventor’s Month

April is National Inventor’s Month, and we wanted to give a shoutout to historical inventors that had a hand in creating the technologies we use every day in our manufacturing and tissue processing lab. Advances in science are incredibly interconnected, requiring the use of materials

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SHIELD preservation and clearing with SmartClear II Pro allows for good light penetration during imaging

Talking transparency: The history and physics of tissue clearing

There is a growing trend among biomedical researchers to interrogate biological structures and biomolecular information in three-dimensional volumes rather than in thin slices. This is particularly the case for neuroscientists looking to spatially map the interactions between the hundreds of unique cell types in the

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Neuropeptide Y staining in mouse brain dorsal cortex

3D labeling and imaging of Neuropeptide Y (NPY) localization in an intact mouse brain hemisphere

Neurons communicate not only via conventional neurotransmitters but also through neuropeptides. Whereas neurotransmitters often operate by changing the excitability of neighboring neurons, neuropeptides typically impact molecular pathways within target cells leading to diverse modulatory effects. Individual neurons can release both a conventional neurotransmitter and one

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