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Whole organ preservation, active clearing and labeling, and light sheet imaging have solved many of the issues related to thin-section histology, including high consumption of time and resources, spotlight bias, and realignment errors. LifeCanvas’s tissue processing pipeline is the world’s only end-to-end solution for processing whole organs from preservation to analysis. Download the white paper to learn more!

Blog Posts

Schematic of Zsigmondy's ultramicroscope

Our favorite inventions for National Inventor’s Month

April is National Inventor’s Month, and we wanted to give a shoutout to historical inventors that had a hand in creating the technologies we use every day in our manufacturing and tissue processing lab. Advances in science are incredibly interconnected, requiring the use of materials

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SHIELD preservation and clearing with SmartClear II Pro allows for good light penetration during imaging

Talking transparency: The history and physics of tissue clearing

There is a growing trend among biomedical researchers to interrogate biological structures and biomolecular information in three-dimensional volumes rather than in thin slices. This is particularly the case for neuroscientists looking to spatially map the interactions between the hundreds of unique cell types in the

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Neuropeptide Y staining in mouse brain dorsal cortex

3D labeling and imaging of Neuropeptide Y (NPY) localization in an intact mouse brain hemisphere

Neurons communicate not only via conventional neurotransmitters but also through neuropeptides. Whereas neurotransmitters often operate by changing the excitability of neighboring neurons, neuropeptides typically impact molecular pathways within target cells leading to diverse modulatory effects. Individual neurons can release both a conventional neurotransmitter and one

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New LifeCanvas tissue process pipeline

Tissue processing in the 21st century

Breathtaking progress in life sciences has brought us innovations such as high-throughput and individually-affordable genomic sequencing as well as next-generation flow cytometry that can phenotype dissociated cells for their expression of dozens of markers simultaneously. The development of cutting-edge technology solutions with standardized workflows has

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Why use intact samples for your research?

Histological analysis has classically been performed on thin tissue sections so that fine-scale features such as individual neuronal cell bodies and cellular processes can be resolved using light microscopy. This tissue-thickness limitation is due to two primary mechanisms: (#1) contamination of the focal plane by

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