Custom Services

Customized whole organ mapping

Using our 3D histology platforms, we offer researchers the capacity for whole-organ molecular phenotyping to derive unbiased and illuminating data. Our versatile methods can be employed to map multiple targets, including specific cell types (e.g. neurons, glia), nuclei, and vasculature. We can also process various organ or sample types using tissue-specific markers.

Pictured above: Mouse duodenum perfused with lectin (red) and immunolabeled with anti-Olfm4 (cyan). Sample courtesy of Dr. Suhail Chaudhry, Ferrara Bone Marrow Transplantation Lab, Icahn School of Medicine.

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Intact mouse right hemisphere dual-labeled with anti-NPY and anti-ChAT, and imaged with SmartSPIM
Mouse right hemisphere dual-labeled with anti-Neuropeptide-Y and anti-ChAT.
PV staining of cells in intact mouse cerebellum, imaged with SmartSPIM
Parvalbumin staining of cells in mouse cerebellum.

Full service tissue processing

Upon receiving your samples, LifeCanvas technicians:

  • Use SHIELD to preserve tissue integrity and antigenicity
  • Actively clear and immunolabel tissue with your selected antibodies or dyes using SmartBatch+
  • Index-match samples with EasyIndex
  • Acquire volumetric light sheet images with SmartSPIM or MegaSPIM
Explore validated targets

From tissue samples to publishable data

You send us: PFA-fixed samples from your experimental animals

Based on your needs, we can provide:

  • Immunolabeling for multiple neuroscience-specific markers (e.g. PV, NeuN, GFAP, IBA1, TH, ChAT, MBP) or tissue-specific targets in other organs
  • Nuclei and vasculature staining in all tissue types
  • Full processing and imaging for diverse tissues, including: spinal cord, kidney, liver, heart, lung, intestine, organoids, tumors
Learn about other applications

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Further reading