SHIELD

Get the first step of tissue processing right with our SHIELD solution kit.

SHIELD tissue preservation kit bottles
SHIELD epoxy bottle
SHIELD ON bottle
SHIELD buffer bottle

Compatible with SmartClear II Pro

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Exceptional protection of fluorescent proteins, tissue integrity, and endogenous molecular information.

VERSATILE

Safeguards endogenous fluorescence, protein antigenicity, nucleic acids, and overall tissue architecture against physical and chemical stressors. Synergizes with a range of existing tissue processing approaches including SWITCH (Cell, 2015), MAP (NBT, 2016), and SmartLabel.

EASY & RELIABLE

Superior tissue preservation, without the variability of hydrogel embedding. Compatible with all PFA-fixed tissues and multiplexing.

FAST & SAFE

Streamlined protocol preserves samples in a matter of days with minimal steps. Reagents are non-toxic and can be easily disposed of after use.

MULTI-ROUND PROTECTION

Protects tissue during fluorescent protein imaging and antibody labeling across multiple rounds.

Click here to learn more about how SHIELD preserves biological tissue.

Technical information:

250-mL SHIELD kit: Preserves 12 whole mouse brains or samples of equivalent size. Includes:

  • SHIELD Epoxy (250 mL)
  • SHIELD Buffer (125 mL)
  • SHIELD ON (250 mL)

500-mL SHIELD kit: Preserves 25 whole mouse brains or samples of equivalent size. Includes:

  • SHIELD Epoxy (500 mL)
  • SHIELD Buffer (250 mL)
  • SHIELD ON (500 mL)
 

Full Pipeline Protocol (includes SHIELD protocol)

SHIELD Epoxy MSDS

SHIELD Buffer MSDS

SHIELD On Buffer MSDS

Brochure

GFP+ motor cortical neurons, imaged with SmartSPIM, courtesy of Prof. Byungkook Lim’s lab, UCSD.
RFP+ spinal cord cells, imaged with SmartSPIM, courtesy of Prof. Helen Lai’s lab, UT Southwestern.

Effective Workflow for PFA-Fixed Tissues

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