SmartLabel

Rapid immunostaining with unparalleled uniformity.

Check out our new batch clearing and labeling device SmartBatch+!

Already own a SmartLabel? You’re eligible for our trade-in program: 40% off each SmartBatch+ for each SmartLabel you trade in.

Fast, Easy, & Efficient

Labels large, intact samples such as rodent organs an order of magnitude faster than with passive labeling (≤ 24 hours vs. weeks to months).

Turnkey operation: simply load the buffers, your sample, and probes. Performs 2 distinct labeling experiments simultaneously thanks to its dual chamber design

Uses a small amount of antibody (as little as ~3 µg) to label tissues the size of a whole mouse brain.

Prevents tissue damage with stochastic electrotransport technology. Our nanoporous membranes (patent pending) eliminate tissue contamination and probe loss.

Complete & Uniform

Achieves unparalleled uniformity of signal intensity from surface to core using LifeCanvas’s advanced eFLASH protocol.

Combines rapid, stochastic electrotransport-mediated infiltration of probes into tissue with the SWITCH technique of controlling probe binding kinetics.

Cost-Efficient

Prevents antibody depletion caused by excessive binding to superficial tissue sites and ensures the sample’s center is well-labeled. 

Compatibility

Anti-GFAP Staining in CA1 Hippocampus of 2-mm Thick Section of Mouse Brain

Volume rendering of anti-GFAP staining in a 2-mm thick section of mouse brain, with signal in CA1 hippocampus most prominent. Labeling achieved in 2 days using antibody electrophoresis performed by SmartLabel. Cleared with SmartClear II Pro (<1 day), refractive index-matched with EasyIndex, and light-sheet imaged with SmartSPIM (<4 minutes acquisition time with 2-µm z-step and 1.8 µm/pixel XY; 2×2 tile using a 3.6x, 0.2 NA objective). See more videos in the video gallery!

SmartLabel: Rapid Immunostaining with Unparalleled Uniformity

SmartLabel, the world’s first active labeling device, combines SWITCH and stochastic electrotransport technologies to quickly and uniformly label whole tissue samples in a fraction of the time needed for passive labeling. Stain an entire mouse brain or rat hemisphere in 24 hours or less and avoid the time-intensive, destructive sectioning and tedious image reconstruction of traditional histology.