SmartLabel

Rapid and strikingly uniform immunostaining

SmartLabel labels large intact samples an order of magnitude faster than passive techniques (≤ 24 hours vs. weeks to months). Our technology achieves unparalleled uniformity of signal intensity from surface to core, and our patent-pending nanoporous membranes eliminate tissue contamination and probe loss.

SL_Crop

Easy and cost-effective

Simply load the buffers, your sample, and probes. Our system can simultaneously perform 2 distinct experiments thanks to its dual chamber design. 

SmartLabel uses as little as 3 µg of antibody to label tissues the size of a whole mouse brain and prevents antibody depletion caused by excessive binding to superficial tissue sites.

Highly compatible

SmartLabel works with many tissue preservation techniques which avoid the loss of endogenous fluorescence and tissue shrinkage present in organic solvent-based clearing methods. SmartLabel is compatible with:

Rapid tissue clearing can be achieved with SmartBatch+ or SmartClear II Pro.

Set up your device

Recent publications citing SmartLabel

Whole-Brain Clearing and Immunolabelling in the African Killifish Nothobranchius furzeri

Augusto Ortega Granillo, Fengyan Deng, Hannah Wilson, Yongfu Wang, Alejandro Sánchez Alvarado

Journal:
Emerging Model Organisms
Publication Date:
Research Area:
Methods
Tissue Species:
Killifish
Tissue Type:
Brain
Products Cited:
SHIELD, EasyIndex, SmartClear, SmartLabel
Arachnoid granulations are lymphatic conduits that communicate with bone marrow and dura-arachnoid stroma

Trishna Shah, Sue E. Leurgans, Rashi I. Mehta, Jingyun Yang, Chad A. Galloway, Karen L. de Mesy Bentley, Julie A. Schneider, Rupal I. Mehta

Journal:
Journal of Experimental Medicine
Publication Date:
Research Area:
Other
Tissue Species:
Human
Tissue Type:
Brain
Products Cited:
SHIELD, EasyIndex, SmartClear, SmartLabel, SmartSPIM
Powassan Virus Induces Structural Changes in Human Neuronal Cells In Vitro and Murine Neurons In Vivo

Jacob Nelson, Lorenzo Ochoa, Paula Villareal, Tiffany Dunn, Ping Wu, Gracie Vargas, Alexander N. Freiberg

Journal:
Pathogens
Publication Date:
Research Area:
Infectious Disease
Tissue Species:
Mouse
Tissue Type:
Brain
Products Cited:
SHIELD, EasyIndex, SmartClear, SmartLabel