SmartLabel

Note: SmartLabel is now a legacy device and our inventory is limited. Check out SmartBatch+ for active batch clearing and labeling functionality in one device.

Tissue labeling - Highlighted pipeline icon

Rapid and strikingly uniform immunostaining

SmartLabel labels large intact samples an order of magnitude faster than passive techniques (≤ 24 hours vs. weeks to months). Our technology achieves unparalleled uniformity of signal intensity from surface to core, and our patent-pending nanoporous membranes eliminate tissue contamination and probe loss.

SmartLabel

Easy and cost-effective

Simply load the buffers, your sample, and probes. Our system can simultaneously perform 2 distinct experiments thanks to its dual chamber design. 

SmartLabel uses as little as 3 µg of antibody to label tissues the size of a whole mouse brain and prevents antibody depletion caused by excessive binding to superficial tissue sites.

Highly compatible

SmartLabel works with many tissue preservation techniques which avoid the loss of endogenous fluorescence and tissue shrinkage present in organic solvent-based clearing methods. SmartLabel is compatible with:

Rapid tissue clearing can be achieved with SmartBatch+ or SmartClear II Pro.

Set up your device

Recent publications citing SmartLabel

A Light sheet fluorescence microscopy and machine learning-based approach to investigate drug and biomarker distribution in whole organs and tumors

Niyanta Kumar, Petr Hrobar, Martin Vagenknecht, Jindrich Soukup, Nadia Patterson, Peter Bloomingdale, Tomoko Freshwater, Sophia Bardehle, Roman Peter, Ruban Mangadu, Cinthia V Pastuskovas, Chiswili Yves Chabu, Mark T. Cancilla

Journal:
bioRxiv
Publication Date:
Research Area:
Neurodegeneration, Cancer, Vasculature, Methods
Tissue Species:
Mouse
Tissue Type:
Brain, Tumor
Products Cited:
SHIELD, EasyIndex, SmartClear, SmartLabel, SmartSPIM, SmartAnalytics, CRO Services
Developmental Mouse Brain Common Coordinate Framework

Fae A. Kronman, Josephine K. Liwang, Rebecca Betty, Daniel J. Vanselow, Yuan-ting Wu, Nicholas J. Tustison, Ashwin Bhandiwad, Steffy B. Manjila, Jennifer A. Minteer, Donghui Shin, Choong Heon Lee, Rohan Patil, Jeffrey T. Duda, Luis Puelles, James C. Gee, Jiangyang Zhang, Lydia Ng, Yongsoo Kim

Journal:
bioRxiv
Publication Date:
Research Area:
Methods, Other
Tissue Species:
Mouse
Tissue Type:
Brain
Products Cited:
SHIELD, EasyIndex, SmartClear, SmartLabel, Passive Clearing Kit, SmartSPIM
Forty-hertz light stimulation does not entrain native gamma oscillations in Alzheimer’s disease model mice

Marisol Soula, Alejandro Martín-Ávila, Yiyao Zhang, Annika Dhingra, Noam Nitzan, Martin J. Sadowski, Wen-Biao Gan, György Buzsáki

Journal:
Nature
Publication Date:
Research Area:
Neurodegeneration
Tissue Species:
Mouse
Tissue Type:
Brain
Products Cited:
SHIELD, EasyIndex, SmartLabel, Passive Clearing Kit, SmartSPIM, SmartAnalytics, CRO Services