The Ultimate Active Immunostaining Device

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Why Early Adopter? 

  • Competitive edge in whole-organ labeling and specialized technical support from our scientists
  • Customized protocol development for your specific sample types and labels of interest

Rapid Immunostaining
with Unparalleled Uniformity

Fast, Easy, and Reliable

Fast: Order of magnitude faster than passive labeling (1-3 days compared to weeks or months)

Easy: Plug-and-play

Reliable: Prevents tissue damage with Stochastic Electrotransport technology (Kim, PNAS, 2015). Our nanoporous membranes (patent-pending) eliminate tissue contamination and probe loss.

Complete and Uniform Labeling

Complete: Full staining of organ-scale samples (e.g., mouse brain)

Uniform: Unparalleled signal uniformity throughout the sample

Cost Savings by Avoiding Target Saturation

Antibody savings: Complete and cost-effective labeling with a small amount of antibody by preventing antibody depletion

SmartLabel is compatible with many clearing techniques including:
  • SWITCH (Murray, Cell, 2015)
  • MAP (Ku, Nature Biotechnology, 2016)
  • SHIELD (Park, Nature Biotechnology, 2018) 

Anti-GFAP Staining in CA1 Hippocampus of 2-mm Thick Section of Mouse Brain

Volume rendering of anti-GFAP staining in a 2-mm thick section of mouse brain, with signal in CA1 hippocampus most prominent. Labeling achieved in 2 days using antibody electrophoresis performed by SmartLabel. Cleared with SmartClear II Pro (<1 day), refractive index-matched with EasyIndex, and light-sheet imaged with SmartSPIM (<4 minutes acquisition time with 2-µm z-step and 1.8 µm/pixel XY; 2×2 tile using a 3.6x, 0.2 NA objective).

SmartLabel: Rapid Immunostaining with Unparalleled Uniformity

SmartLabel, the world’s first active labeling device, combines SWITCH and stochastic electrotransport technologies to quickly and uniformly label whole tissue samples in a fraction of the time needed for passive labeling. Stain an entire mouse brain or rat hemisphere in just 2 days and avoid the time-intensive, destructive sectioning and tedious image reconstruction of traditional histology.