Dr. Emily Newman is a postdoctoral research fellow in the Ressler lab at the McLean Hospital and Harvard Medical School....
c-FOS is a protein derived from immediate early gene expression and is recognized as a specific marker of neuronal activity throughout the mammalian brain. Through a variety of perturbations (e.g. drug treatments, external stimuli), expression levels become elevated. By detecting c-FOS+ cells throughout tissue volumes via immunolabeling, imaging, and analyses, neural activity can be visualized, mapped, and quantified throughout the brain.
We have perfected technology to label and image these cells throughout the CNS. We also offer robust models for detecting positive cells in murine brain samples and provide cell counts, densities, and heat maps quantifying levels of regional neural activity registered to the Allen Brain Atlas.
Above: c-FOS in whole rat brain. Click for higher resolution of zoomed-in region.
Header: c-FOS (green) and cell detection (red) in mouse hippocampus and cortex.
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You send us: PFA-fixed samples from your experimental animals
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Dr. Emily Newman is a postdoctoral research fellow in the Ressler lab at the McLean Hospital and Harvard Medical School....
Dr. Erin Hisey is a postdoctoral research fellow in the Ressler lab at the McLean Hospital and Harvard Medical School....
Mapping the localization of increased c-FOS expression provides important insights into specific brain regions implicated in the responses to a...