Ph.D. candidate Kaitlyn Dorst uses LifeCanvas CRO services to investigate the underpinnings of fear memories in mice.
c-FOS is a protein derived from immediate early gene expression and is recognized as a specific marker of neuronal activity throughout the mammalian brain. Through a variety of perturbations (e.g. drug treatments, external stimuli), expression levels become elevated. By detecting c-FOS+ cells throughout tissue volumes via immunolabeling, imaging, and analyses, neural activity can be visualized, mapped, and quantified throughout the brain.
We have fine-tuned our technology to label and image these cells throughout the CNS. We also offer robust models for detecting positive cells in murine brain samples and provide cell counts, densities, and heat maps quantifying levels of regional neural activity registered to the Allen Brain Atlas.
Above: c-FOS in whole rat brain. Click for higher resolution of zoomed-in region.
Upon receiving your samples, LifeCanvas technicians:
You send us: PFA-fixed samples from your experimental animals
Through our interactive data delivery platform, we provide:
Ph.D. candidate Kaitlyn Dorst uses LifeCanvas CRO services to investigate the underpinnings of fear memories in mice.
Dr. Rafael Perez leverages LifeCanvas CRO services to study the neurological effects of environmental context on opioid tolerance.
Dr. Emily Newman uses LifeCanvas' c-FOS mapping services to study the underpinnings of aggressive behavior in female mice.
Dr. Erin Hisey uses LifeCanvas' c-FOS mapping services to study the effects of social defeat in juvenile mice.
Header: c-FOS (green) and cell detection (red) in mouse hippocampus and cortex.