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Introducing Megatome & MegaSPIM: new tools for processing and imaging
an unparalleled range of tissue samples

Megatome is a vibrating microtome designed for precision high-frequency sectioning of tissues from organoids and biopsy samples to expanded rodent brains and intact human organs. Megatome enables high-throughput tissue sectioning with uniform surface profile, plus minimal tissue damage and information loss.

MegaSPIM is a light sheet microscope developed for high-resolution imaging of tissues as diverse as thin sections, cleared thick sections of human or other primate organs, and arrays of smaller cleared samples such as whole rodent organs or organoids.

Pioneering end-to-end solutions for spatial biology

Tissue Preservation
Optical Clearing
Light Sheet Imaging
3D Image Analysis

Astrocytes marked by GFAP (magenta) cluster around β-amyloid plaques (cyan) in brain of 7-month-old homozygous ARTE10 male mouse (model #16347) from Taconic Biosciences.

Tissue preparation for 3D histology & imaging

The LifeCanvas portfolio is optimized for whole organs and multi-sample processing to simplify your research workflow and improve your data outputs. SHIELD tissue preservation, combined with Clear+ and EasyIndex tissue clearing, ensure conservation of molecular information and safe removal of light-scattering lipids.

Sleek and easy to use, SmartBatch+ is the only system of its kind: high-throughput processing combined with electrophoretic tissue clearing and immunolabeling functions make it an asset to any laboratory.

Light sheet microscope with unmatched acquisition speed & axial resolution

The SmartSPIM light sheet microscope is designed for high speed, high resolution volumetric imaging. Image an intact mouse brain hemisphere or comparably sized sample in <30 minutes, while maintaining uniform axial resolution throughout the field of view.

SmartSPIM’s large imaging chamber with dual illumination enables multi-sample acquisition and accommodates tissues from organoids, to rat brains, to entire juvenile mice. The microscope’s modular design allows you to upgrade individual parts and tailor the system to your needs.

Thy1-driven YFP expression visualized throughout adult mouse brain. Sample courtesy of Dr. G. Allan Johnson, Duke University Center for In Vivo Microscopy.

Whole organ mapping services

Send in your PFA-fixed samples and gain access to these innovative tools along with LifeCanvas’ extensive expertise in tissue processing, imaging, and analysis. Explore endogenous fluorescence and a variety of stains and biomarkers in many tissue and sample types, including: brain, spinal cord, kidney, lung, liver, tumors, and organoids.

Neuroscience researchers can leverage LifeCanvas’ robust brain mapping pipeline, including full-service studies of cFOS expression and neurodegenerative disease phenotypes.

LifeCanvas Portraits:
Kaitlyn Dorst

We spoke to Kaitlyn Dorst, a Ph.D. candidate in the Ramirez lab at Boston University, about her work using optogenetic tools to study fear engrams in mice. Learn more about Kaitlyn's research and how LifeCanvas helps her examine brain-wide changes in mammalian fear memory networks.

LifeCanvas Portraits:
Dr. Rafael Perez

Dr. Rafael Perez, a postdoctoral associate in the Picciotto lab at the Yale School of Medicine, talked to us about his research investigating the neurological effects of environmental context on opioid tolerance. Learn more about Dr. Perez's work and how LifeCanvas services help him identify brain regions and cell ensembles involved in this process.

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