End-to-end solutions for
3D spatial biology

LifeCanvas’ pipeline empowers scientists with spatially-resolved insights from intact tissues. Accelerate your studies with high-resolution, high-throughput molecular readouts, all while maintaining biologically accurate morphology.

Comprehensive molecular mapping, from sample to data.

From neuroscience to oncology, whole organs to organoids, LifeCanvas offers a unique end-to-end pipeline tailor-made for your research application. Our automated tools and proprietary technologies will streamline your workflow and improve your data outputs with unprecedented speed, accuracy, depth, and cost-effectiveness. We partner with you to obtain unbiased data that will drive your studies forward and enable breakthrough discoveries.

Sample Preparation

Optimize samples for imaging with advanced techniques for tissue preservation, clearing, and labeling.

Light Sheet Imaging

Easily capture 3D image data from a wide range of tissue types and sizes with unmatched acquisition speed and resolution.

3D Data Analysis

Leverage AI-powered cell detection algorithms to generate robust analysis outputs from 3D image data.

Introducing DALISPIM

Open-top light sheet microscope for easy, scalable imaging workflows

Our newest system packs the resolution and speed of our other microscopes into an open-top, inverted configuration. DALISPIM is readily automatable and perfect for seamless high-throughput imaging, from whole tissues in multiwell plates to slide-mounted sections and beyond.

Recently published studies

Modified AAV5 Capsid for Improved Brain Biodistribution Following Direct Injection in Preclinical Models

Sebastian N. Kieper, Elisabeth A. Spronck, Meriem Bourajjaj, Roberto D.V.S Morais, M. Leontien van der Bent, Seyda Acar Broekmans, Charlot van Rooijen, Rhodé van Westen, Giorgia Squeri, Giso Brasser, Morgane Wartel, Stijn J.H. Waaijer, C.Warner Hoornenborg, Tycho M. Hoogland, Richard Porter, Angga Kusuma

Journal:
Molecular Therapy Methods & Clinical Development
Publication Date:
Research Area:
Biodistribution
Tissue Species:
Mouse
Tissue Type:
Brain
Products Cited:
SHIELD, EasyIndex, SmartBatch+, SmartSPIM, SmartAnalytics, CRO Services
Microglia alter sex-specific cerebellar myelination following placental hormone loss

Jacquelyn Salzbank, Helene Lacaille, Jenah Gaby, Jiaqi J. O’Reilly, Michael Kissner, Claire-Marie Vacher & Anna A. Penn

Journal:
Nature Communications
Publication Date:
Research Area:
Neurodevelopmental Disorders
Tissue Species:
Mouse
Tissue Type:
Brain
Products Cited:
SHIELD, SmartBatch+, SmartSPIM, SmartAnalytics, CRO Services
A microphysiological system for screening lipid nanoparticle−mRNA complexes predicts in vivo heart transfection efficacy

Gabriel Neiman, Mauro W. Costa, Hesong Han, Sheng Zhao, Tammy K. Ng, Brian Siemons, Tomohiro Nishino, Yu Huang, Shyam Lal, Kenneth Wu, Luke M. Judge, Bruce R. Conklin, Deepak Srivastava, Niren Murthy & Kevin E. Healy

Journal:
Nature Biomedical Engineering
Publication Date:
Research Area:
Cardiovascular, Biodistribution
Tissue Species:
Mouse
Tissue Type:
Heart
Products Cited:
SmartSPIM

LifeCanvas Portraits: Conversations with our scientific community

LifeCanvas Portraits: Dr. Paula Montero Llopis

Dr. Montero Llopis shares her insights on the MicRoN Core’s vision, its adoption of LifeCanvas technologies, and how our values align to support scientific advancement.

LifeCanvas Portraits: Tanya Daigle

Dr. Tanya Daigle used LifeCanvas' Services to acquire 3D images of spinal motor neurons illuminated by enhancer AAV.

LifeCanvas Portraits: Dr. Sam Centanni

Dr. Sam Centanni uses the LifeCanvas pipeline to investigate the neurobiological overlap between stress and predisposition to alcohol abuse, as well as long-term effects of alcohol on the brain.

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