SmartClear II Pro

Note: SmartClear is now a legacy device and our inventory is limited. Check out SmartBatch+ for active batch clearing and labeling functionality in one device.

Tissue Clearing - Highlighted pipeline icon

Active tissue clearing made easy

SmartClear II Pro is ready-to-use, an order of magnitude faster than passive clearing, and provides optimal imaging and staining quality. Our SmartClear system effectively delipidates for best antibody diffusion and minimal light scatter, and ensures maximum preservation of fluorescent protein signals with optimized buffers that maintain pH.

Patent-pending nanoporous membranes prevent common issues including tissue damage, contamination, browning, black precipitates, and deformation.

SmartClear II Pro
Sample Holders

Efficient and cost-effective

SmartClear II Pro can clear 4 whole mouse brains, 2 rat brains, or similarly sized samples simultaneously. Its customizable larger chamber enables clearing of various sample types and sizes to suit your needs.

Our Clear+ tissue clearing buffer set maximizes optical transparency, minimizes clearing time, and lasts ~10 days without losing efficacy. Plus, there is no tissue shrinkage or expansion!

Highly compatible

SmartClear II Pro works with many tissue preservation techniques which avoid the loss of endogenous fluorescence and tissue shrinkage present in organic solvent-based methods. The SmartClear system is compatible with:

Uniform, rapid intact tissue staining can then be achieved SmartBatch+.

Set up your device

Recent publications citing SmartClear

A Light sheet fluorescence microscopy and machine learning-based approach to investigate drug and biomarker distribution in whole organs and tumors

Niyanta Kumar, Petr Hrobar, Martin Vagenknecht, Jindrich Soukup, Nadia Patterson, Peter Bloomingdale, Tomoko Freshwater, Sophia Bardehle, Roman Peter, Ruban Mangadu, Cinthia V Pastuskovas, Chiswili Yves Chabu, Mark T. Cancilla

Journal:
bioRxiv
Publication Date:
Research Area:
Neurodegeneration, Cancer, Vasculature, Methods
Tissue Species:
Mouse
Tissue Type:
Brain, Tumor
Products Cited:
SHIELD, EasyIndex, SmartClear, SmartLabel, SmartSPIM, SmartAnalytics, CRO Services
Developmental Mouse Brain Common Coordinate Framework

Fae A. Kronman, Josephine K. Liwang, Rebecca Betty, Daniel J. Vanselow, Yuan-ting Wu, Nicholas J. Tustison, Ashwin Bhandiwad, Steffy B. Manjila, Jennifer A. Minteer, Donghui Shin, Choong Heon Lee, Rohan Patil, Jeffrey T. Duda, Luis Puelles, James C. Gee, Jiangyang Zhang, Lydia Ng, Yongsoo Kim

Journal:
bioRxiv
Publication Date:
Research Area:
Methods, Other
Tissue Species:
Mouse
Tissue Type:
Brain
Products Cited:
SHIELD, EasyIndex, SmartClear, SmartLabel, Passive Clearing Kit, SmartSPIM
Glutamatergic Supramammillary Nucleus Neurons Respond to Threatening Stressors and Promote Active Coping

Abraham Escobedo, Salli-Ann Holloway, Megan Votoupal, Aaron L. Cone, Hannah E. Skelton, Alex A. Legaria, Imeh Ndiokho, Tasheia Floyd, Alexxai V. Kravitz, Michael R. Bruchas, Aaron J. Norris

Journal:
bioRxiv
Publication Date:
Research Area:
Neural Circuits
Tissue Species:
Mouse
Tissue Type:
Brain
Products Cited:
SHIELD, EasyIndex, SmartClear, SmartSPIM, CRO Services