SmartClear II Pro

The Multi-Purpose Tissue Clearing System
You've Been Waiting For

NEW USERS – Sign up for our New User Startup Program to be eligible for a free training session, consultations with our experts, and extended reagent discounts!

Examples of cleared and refractive index-matched tissue types

SmartClear II Pro sample cup and customizable mesh bags

Check out our New Customizable Sample Holder!

Compatible with almost any sample, this new design will keep your samples safe and secure.

Enjoy batch tissue clearing while keeping costs low and samples protected

Multi-Purpose Function

Batch Processing and Customization: 4 whole mouse brains or 2 rat brains can be cleared simultaneously. Larger clearing chamber enables clearing of various sample types and sizes that can be customized according to your needs.

Cost-Effective Clearing of Bulk Quantity

Cost-effective and Eco-friendly: New-generation buffer set lasts around 10 days without loss of its clearing ability. Lower running costs for samples as the same volume of buffer is used regardless of size and number of samples.

Fast, Easy, and Reliable

Fast & Easy: Order of magnitude faster than passive clearing. Our ready-to-use technologies bring plug-and-play options to clearing.

Reliable: Prevents tissue damage with stochastic electrotransport technology (Kim, PNAS, 2015). Our nanoporous membranes (patent-pending) eliminate tissue contamination, tissue browning, black precipitates and tissue deformation while providing uniform clearing.

Exportable Clearing History & Data

Perfect Clearing with Maximal FP Signal Preservation

FP Signals: Maximum preservation of fluorescent protein (FP) signals with optimized buffers that maintain pH.

Optical Clarity: Minimum light scatter. Removes lipid best for best antibody diffusion. Optimal imaging and staining quality that is compatible with SmartLabel, our rapid staining system for intact samples.

Clearing Technique Compatibility and Comparisons

SmartClear II Pro is compatible with many tissue preservation techniques including:

These methods avoid the loss of endogenous fluorescence and tissue shrinkage present in organic solvent-based clearing methods like BABB, iDisco, uDisco, 3DISCO, and vDISCO.

Versatile Sample Holders

Device Setup


SmartClear tissue clearing buffers

Clearing Buffers

Optimized for tissue clearing
Long life time (up to 10 days)

EasyIndex bottles

EasyIndex (RI=1.46)

Optical clearing solution compatible
Cost-effective and convenient