SmartClear II Pro

The multi-purpose tissue clearing system you've been waiting for.

NEW USERS: Sign up for our New User Startup Program to be eligible for a free training session, consultations with our experts, and extended reagent discounts!

Check out our new batch clearing and labeling device SmartBatch+!

Examples of cleared & refractive index-matched tissue types


4 whole mouse brains or 2 rat brains can be cleared simultaneously. Larger clearing chamber enables clearing of various sample types and sizes that can be customized according to your needs.


New-generation buffer set lasts around 10 days without loss of its clearing ability. Lower running costs for samples, as the same volume of buffer is used regardless of size and number of samples.

Fast, Easy, & Reliable

Order of magnitude faster than passive clearing. Our ready-to-use technologies bring plug-and-play options to clearing.

Prevents tissue damage with stochastic electrotransport technology. Our nanoporous membranes (patent pending) eliminate tissue contamination, tissue browning, black precipitates, and tissue deformation while providing uniform clearing.

Perfect Clearing

Maximum preservation of fluorescent protein (FP) signals with optimized buffers that maintain pH.

Removes lipids for best antibody diffusion and minimal light scatter. Optimal imaging and staining quality that is compatible with SmartLabel, our rapid staining system for intact samples.

Compatibility & Comparisons

SmartClear II Pro is compatible with many tissue preservation techniques including:

These methods avoid the loss of endogenous fluorescence and tissue shrinkage present in organic solvent-based clearing methods like BABB, iDisco, uDisco, 3DISCO, and vDISCO.

SmartClear II Pro sample cup and customizable mesh bags

Check out our customizable sample holder! Compatible with almost any sample, this new design will keep your samples safe and secure.


Clearing Buffers

  • Optimized for tissue clearing
  • Long lifetime (up to 10 days)
  • Eco-friendly
  • EasyIndex (RI=1.52, 1.46)

  • Optical clearing solution compatible with SHIELD, SWITCH, & MAP
  • Cost-effective and convenient