SmartClear II Pro is ready-to-use, an order of magnitude faster than passive clearing, and provides optimal imaging and staining quality. Our SmartClear system effectively delipidates for best antibody diffusion and minimal light scatter, and ensures maximum preservation of fluorescent protein signals with optimized buffers that maintain pH.
Patent-pending nanoporous membranes prevent common clearing issues including tissue damage, contamination, browning, black precipitates, and deformation.
SmartClear II Pro can clear 4 whole mouse brains, 2 rat brains, or similarly sized samples simultaneously. Its customizable larger clearing chamber enables clearing of various sample types and sizes to suit your needs.
Our Clear+ tissue clearing buffer set maximizes optical transparency, minimizes clearing time, and lasts ~10 days without loss of clearing ability. Plus, there is no tissue shrinkage or expansion!
SmartClear II Pro works with many tissue preservation techniques which avoid the loss of endogenous fluorescence and tissue shrinkage present in organic solvent-based clearing methods, including:
Muñoz-Castañeda et al. “Cellular Anatomy of the Mouse Primary Motor Cortex.” Nature (October 2021).