LifeCanvas Portraits: Dr. Jose Maldonado

Jose Maldonado, Managing Director of Vanderbilt’s NeuroVisualization Lab, discusses his neuroscience research interests and how LifeCanvas’ imaging and analysis platforms helped quantify crucial data in his co-authored study published in Nature Communications this June.

How 3D tissue clearing benefits COVID-19 research

Over 190 million people have now been infected with the novel coronavirus SARS-CoV-2 in the ongoing coronavirus disease (COVID-19) pandemic with a total number of deaths passing 4.1 million worldwide. Multiple organs are affected by COVID-19, however, the lungs are the main site of disease.

Recent publications leverage 3D histology to provide new insights into neuronal circuitry

3D neuronal projections in a whole mouse brain (Luchsinger et al., Nat Commun. 2021, Supplementary Movie 1). Licensed under CC BY 4.0.

The goal of histology has long been to interrogate complex structures in whole tissue samples. Over centuries, slicing of samples for traditional two-dimensional histology has been indispensable in understanding the structure and morphology of multiple tissue types. However, this approach is limited to yielding images in thin tissue sections, is time-consuming and is error-prone due to tissue distortion and information loss.

Upcoming publications to watch

Mouse spinal cord expressing tdTomato. Sample courtesy of Lai Lab, UT Southwestern.

Check out these upcoming publications utilizing LifeCanvas products and technologies! Our tissue processing methods and devices are utilized around the world to further medical and biological research, facilitating new discoveries and improving lives. The articles below are posted prior to peer-review in open-access medRxiv and bioRxiv online repositories.