SmartClear II Pro

Note: SmartClear is now a legacy device and our inventory is limited. Check out SmartBatch+ for active batch clearing and labeling functionality in one device.

Tissue Clearing - Highlighted pipeline icon

Active tissue clearing made easy

SmartClear II Pro is ready-to-use, an order of magnitude faster than passive clearing, and provides optimal imaging and staining quality. Our SmartClear system effectively delipidates for best antibody diffusion and minimal light scatter, and ensures maximum preservation of fluorescent protein signals with optimized buffers that maintain pH.

Patent-pending nanoporous membranes prevent common issues including tissue damage, contamination, browning, black precipitates, and deformation.

SmartClear II Pro
Sample Holders

Efficient and cost-effective

SmartClear II Pro can clear 4 whole mouse brains, 2 rat brains, or similarly sized samples simultaneously. Its customizable larger chamber enables clearing of various sample types and sizes to suit your needs.

Our Clear+ tissue clearing buffer set maximizes optical transparency, minimizes clearing time, and lasts ~10 days without losing efficacy. Plus, there is no tissue shrinkage or expansion!

Highly compatible

SmartClear II Pro works with many tissue preservation techniques which avoid the loss of endogenous fluorescence and tissue shrinkage present in organic solvent-based methods. The SmartClear system is compatible with:

Uniform, rapid intact tissue staining can then be achieved SmartBatch+.

Set up your device

Recent publications citing SmartClear

MarShie: a clearing protocol for 3D analysis of single cells throughout the bone marrow at subcellular resolution

Till Fabian Mertens, Alina Tabea Liebheit, Johanna Ehl, Ralf Köhler, Asylkhan Rakhymzhan, Andrew Woehler, Lukas Katthän, Gernot Ebel, Wjatscheslaw Liublin, Ana Kasapi, Antigoni Triantafyllopoulou, Tim Julius Schulz, Raluca Aura Niesner & Anja Erika Hauser.

Journal:
Nature Communications
Publication Date:
Research Area:
Other
Tissue Species:
Mouse
Products Cited:
SHIELD, EasyIndex, SmartClear
Opioid-driven disruption of the septal complex reveals a role for neurotensin-expressing neurons in withdrawal

Rhiana C. Simon, Weston T. Fleming, Pranav Senthilkumar, Brandy A. Briones1,2, Kentaro K. Ishii, Madelyn M. Hjort, Madison M. Martin, Koichi Hashikawa, Andrea D. Sanders, Sam A. Golden, Garret D. Stuber.

Journal:
bioRxiv
Publication Date:
Research Area:
Neural Circuits, Other
Tissue Species:
Mouse
Tissue Type:
Brain
Products Cited:
SHIELD, EasyIndex, SmartClear, SmartSPIM
Hippocampal Engrams Generate Variable Behavioral Responses and Brain-Wide Network States

Kaitlyn E. Dorst, Ryan A. Senne, Anh H. Diep, Antje R. de Boer, Rebecca L. Suthard, Heloise Leblanc, Evan A. Ruesch, Angela Y. Pyo, Sara Skelton, Lucas C. Carstensen, Samantha Malmberg, Olivia P. McKissick, John H. Bladon and Steve Ramirez.

Journal:
The Journal of Neuroscience
Publication Date:
Tissue Type:
Brain
Products Cited:
SHIELD, EasyIndex, SmartClear, SmartLabel, SmartSPIM, CRO Services