End-to-end solutions for
3D spatial biology

LifeCanvas’ pipeline empowers scientists with spatially-resolved insights from intact tissues. Accelerate your studies with high-resolution, high-throughput molecular readouts, all while maintaining biologically accurate morphology.

Comprehensive molecular mapping, from sample to data.

From neuroscience to oncology, whole organs to organoids, LifeCanvas offers a unique end-to-end pipeline tailor-made for your research application. Our automated tools and proprietary technologies will streamline your workflow and improve your data outputs with unprecedented speed, accuracy, depth, and cost-effectiveness. We partner with you to obtain unbiased data that will drive your studies forward and enable breakthrough discoveries.

Sample Preparation

Optimize samples for imaging with advanced techniques for tissue preservation, clearing, and labeling.

Light Sheet Imaging

Easily capture 3D image data from a wide range of tissue types and sizes with unmatched acquisition speed and resolution.

3D Data Analysis

Leverage AI-powered cell detection algorithms to generate robust analysis outputs from 3D image data.

Introducing DALISPIM

Open-top light sheet microscope for easy, scalable imaging workflows

Our newest system packs the resolution and speed of our other microscopes into an open-top, inverted configuration. DALISPIM is readily automatable and perfect for seamless high-throughput imaging, from whole tissues in multiwell plates to slide-mounted sections and beyond.

Recently published studies

Concordant transcriptional and morphological remodeling revealed by in vivo Perturb-CLEAR

Boli Wu, Sean K. Simmons, Seoyeon Kim, Jiwen Li, Masood A. Akram, Chang Sin Park, Xinhe Zheng, Iain Mendez, Sasha Patel, Alan Chau, Nadia Burciu, Pranay Dayal, Thokozile Nyasulu, Nhan Huynh, Grace S. Clarke, X. William Yang, Joshua Z. Levin, Xin Jin

Journal:
bioRxiv
Publication Date:
Research Area:
Neurodevelopmental Disorders
Tissue Species:
Mouse
Tissue Type:
Brain
Products Cited:
SHIELD, EasyIndex, Passive Clearing Kit, SmartSPIM
Distinct neurogenic pathways shape the diversification and mosaic organization of cortical output channels

Shreyas M. Suryanarayana, Xu An, Yongjun Qian, Shengli Zhao, Hemanth Mohan, Z. Josh Huang

Journal:
Neuron
Publication Date:
Research Area:
Neural Circuits
Tissue Species:
Mouse
Tissue Type:
Brain
Products Cited:
SHIELD, EasyIndex, SmartBatch+, SmartSPIM, CRO Services
The midbrain reticular formation in contextual control of perceptual decisions

Jordan R. Shaker, Jeremy N. Schroeter, Daniel Birman, Nicholas A. Steinmetz

Journal:
Neuron
Publication Date:
Research Area:
Neural Circuits
Tissue Species:
Mouse
Tissue Type:
Brain
Products Cited:
SHIELD, EasyIndex, Passive Clearing Kit, SmartSPIM

LifeCanvas Portraits: Conversations with our scientific community

Headshot of Dr. Paula Montero Llopis: A person with curly hair smiles softly, wearing a black floral-patterned top. The blurred background suggests an indoor setting.

LifeCanvas Portraits: Dr. Paula Montero Llopis

Dr. Montero Llopis shares her insights on the MicRoN Core’s vision, its adoption of LifeCanvas technologies, and how our values align to support scientific advancement.

LifeCanvas Portraits: Tanya Daigle

Dr. Tanya Daigle used LifeCanvas' services to acquire 3D images of spinal motor neurons illuminated by enhancer AAV.

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