End-to-end solutions for
3D spatial biology

LifeCanvas’ pipeline empowers scientists with spatially-resolved insights from intact tissues. Accelerate your studies with high-resolution, high-throughput molecular readouts, all while maintaining biologically accurate morphology.

Comprehensive molecular mapping, from sample to data.

From neuroscience to oncology, whole organs to organoids, LifeCanvas offers a unique end-to-end pipeline tailor-made for your research application. Our automated tools and proprietary technologies will streamline your workflow and improve your data outputs with unprecedented speed, accuracy, depth, and cost-effectiveness. We partner with you to obtain unbiased data that will drive your studies forward and enable breakthrough discoveries.

Sample Preparation

Optimize samples for imaging with advanced techniques for tissue preservation, clearing, and labeling.

Light Sheet Imaging

Easily capture 3D image data from a wide range of tissue types and sizes with unmatched acquisition speed and resolution.

3D Data Analysis

Leverage AI-powered cell detection algorithms to generate robust analysis outputs from 3D image data.

Introducing DALISPIM

Open-top light sheet microscope for easy, scalable imaging workflows

Our newest system packs the resolution and speed of our other microscopes into an open-top, inverted configuration. DALISPIM is readily automatable and perfect for seamless high-throughput imaging, from whole tissues in multiwell plates to slide-mounted sections and beyond.

Recently published studies

A Neural Arming Niche in Tumor-Draining Lymph Nodes Programs CD8⁺T Cell Cytotoxicity via GZMB Norepinephrinylation

Yan Yang, Xue-Li Zhang, Aziguli Tulamaiti, Shu-Yu Xiao, Yun-Zhen Qian, Jia-Mei Luo, Guang-hong Su, Rui Lu, Jun-Jie Wang, Hong-Tai Ma, Xia-Qing Li, Wen-Tao Shi, Yuan-Xin Hong, Jing-Li Hou, Li-Peng Hu, Xin Xing, Qing Li, Dong-Xue Li, Zhi-Gang Zhang

Journal:
bioRxiv
Publication Date:
Research Area:
Cancer
Tissue Species:
Mouse
Tissue Type:
Lymph Node, Tumor
Products Cited:
EasyIndex, MegaSPIM
Magnetic resonance microscopy maps widespread effects of Alzheimer’s disease on brain structures and behavior in mice

Yuqi Tian, Kathryn Hornburg, Wyatt Austin, James J. Cook, Yi Qi, Leonard E. White, John T. Killmar, Catherine C. Kaczorowski, David G. Ashbrook, G. Allan Johnson & Robert W. Williams

Journal:
Nature Neuroscience
Publication Date:
Research Area:
Neurodegeneration
Tissue Species:
Mouse
Tissue Type:
Brain
Products Cited:
SHIELD, SmartBatch+, SmartSPIM, CRO Services
Competitive cell transplantation in rat mammary tissue and its use for radiation-induced cell competition and tumor clonality assays

Kento Nagata, Yukiko Nishimura-Yano, Ayaka Hosoki, Ken-ichi Kudo, Kazuhiro Daino, Mayumi Nishimura, Tatsuhiko Imaoka

Journal:
Journal of Radiation Research
Publication Date:
Research Area:
Cancer
Tissue Species:
Rat
Products Cited:
EasyIndex, SmartClear

LifeCanvas Portraits: Conversations with our scientific community

LifeCanvas Portraits: Dr. Paula Montero Llopis

Dr. Montero Llopis shares her insights on the MicRoN Core’s vision, its adoption of LifeCanvas technologies, and how our values align to support scientific advancement.

LifeCanvas Portraits: Tanya Daigle

Dr. Tanya Daigle used LifeCanvas' Services to acquire 3D images of spinal motor neurons illuminated by enhancer AAV.

LifeCanvas Portraits: Dr. Sam Centanni

Dr. Sam Centanni uses the LifeCanvas pipeline to investigate the neurobiological overlap between stress and predisposition to alcohol abuse, as well as long-term effects of alcohol on the brain.

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