End-to-end solutions for
3D spatial biology

LifeCanvas’ pipeline empowers scientists with spatially-resolved insights from intact tissues. Accelerate your studies with high-resolution, high-throughput molecular readouts, all while maintaining biologically accurate morphology.

Comprehensive molecular mapping, from sample to data.

From neuroscience to oncology, whole organs to organoids, LifeCanvas offers a unique end-to-end pipeline tailor-made for your research application. Our automated tools and proprietary technologies will streamline your workflow and improve your data outputs with unprecedented speed, accuracy, depth, and cost-effectiveness. We partner with you to obtain unbiased data that will drive your studies forward and enable breakthrough discoveries.

Sample Preparation

Optimize samples for imaging with advanced techniques for tissue preservation, clearing, and labeling.

Light Sheet Imaging

Easily capture 3D image data from a wide range of tissue types and sizes with unmatched acquisition speed and resolution.

3D Data Analysis

Leverage AI-powered cell detection algorithms to generate robust analysis outputs from 3D image data.

Introducing DALISPIM

Open-top light sheet microscope for easy, scalable imaging workflows

Our newest system packs the resolution and speed of our other microscopes into an open-top, inverted configuration. DALISPIM is readily automatable and perfect for seamless high-throughput imaging, from whole tissues in multiwell plates to slide-mounted sections and beyond.

Recently published studies

Intestinal interoceptive dysfunction drives age-associated cognitive decline

Timothy O. Cox, Ashwarya S. Devason, Alan de Araujo, Sydney Mason, Madhav Subramanian, Andrea F. M. Salvador, Hélène C. Descamps, Junwon Kim, Yixuan Zhu, Lev Litichevskiy, Sunhee Jung, Won-Suk Song, Adrián Cortés-Martín, Nathan T. Henderson, Kuei-Pin Huang, Thao Nguyen, Wisath Sae-Lee, Iboro C. Umana, Maria Sacta, Ryan J. Rahman, Stephen Wisser, J. Andrew D. Nelson, Ilona Golynker, Alana M. McSween, Eric F. Hohmann, Shaan Patel, Anna L. Bub, Clara Soekler, Niklas Blank, Kevt’her Hoxha, Lavinia Boccia, Andrea C. Wong, Klaas Bahnsen, Jihee Kim, Natalie Biderman, Dina Abbasian, Clarissa Shoffler, Christopher Petucci, Fiona E. McAllister, Amber L. Alhadeff, Marc V. Fuccillo, Colin Hill, Cholsoon Jang, J. Nicholas Betley, Guillaume de Lartigue, Virginia Y.-M. Lee, Maayan Levy & Christoph A. Thaiss

Journal:
Nature
Publication Date:
Tissue Species:
Mouse
Tissue Type:
Whole Body
Products Cited:
SHIELD, EasyIndex, SmartSPIM, CRO Services
Brain-wide mapping and synaptic localization of C1QL3 using a novel epitope-tagged knock-in mouse

William P. Armstrong IV, James M. Salvatore, Matthew J. Sticco, Keaven Caro, J. Wesley Maddox, Angie Huang, Brenna C. McAllister, Christopher O’Connell, Siu-Pok Yee, Amy Lee, Susanne Ressl, David C. Martinelli, Alexander C. Jackson

Journal:
biorXiv
Publication Date:
Tissue Species:
Mouse
Tissue Type:
Brain
Products Cited:
SHIELD, EasyIndex, SmartBatch+, SmartSPIM, SmartAnalytics, CRO Services, Radiant
A Neural Arming Niche in Tumor-Draining Lymph Nodes Programs CD8⁺T Cell Cytotoxicity via GZMB Norepinephrinylation

Yan Yang, Xue-Li Zhang, Aziguli Tulamaiti, Shu-Yu Xiao, Yun-Zhen Qian, Jia-Mei Luo, Guang-hong Su, Rui Lu, Jun-Jie Wang, Hong-Tai Ma, Xia-Qing Li, Wen-Tao Shi, Yuan-Xin Hong, Jing-Li Hou, Li-Peng Hu, Xin Xing, Qing Li, Dong-Xue Li, Zhi-Gang Zhang

Journal:
bioRxiv
Publication Date:
Research Area:
Cancer
Tissue Species:
Mouse
Tissue Type:
Lymph Node, Tumor
Products Cited:
EasyIndex, MegaSPIM

LifeCanvas Portraits: Conversations with our scientific community

LifeCanvas Portraits: Dr. Paula Montero Llopis

Dr. Montero Llopis shares her insights on the MicRoN Core’s vision, its adoption of LifeCanvas technologies, and how our values align to support scientific advancement.

LifeCanvas Portraits: Tanya Daigle

Dr. Tanya Daigle used LifeCanvas' Services to acquire 3D images of spinal motor neurons illuminated by enhancer AAV.

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