Neural Activity Mapping | Identify activated neurons and brain regions

Neural Activity Mapping

Use Case: Identify activated neurons and brain regions

High-throughput brain-wide activity screening:

Precision
Insights:

Unbiased and comprehensive comparisons:

Our high-content, high-throughput tissue processing and imaging platform enables comprehensive brain-wide comparisons of neural activities across multiple cohorts with confidence and speed.

Whole brain IEG immunolabeling (e.g., cFos, ΔFosB, Arc), single-cell resolution imaging with automated and custom atlas registration enables precise identification of brain regions with altered activity.

Pan-regional comparisons across cohorts enable efficient and unbiased discovery without the need for prior knowledge of potentially activated regions. Discover shared and distinct activation patterns across various contexts such as mutations, treatments, dimorphisms, and more. 

For additional publications supporting this use case refer to:

  • Tan et al. (2024) Science
  • Yang et al. (2024) Neuron: Figure 5 shows how is pPDH inversely correlated with neural activity in water deprivation models.
  • Wasilczuk et al. (2024) PNAS: Figure 4 illustrates fewer c-Fos-positive neurons in sleep-promoting hypothalamic nuclei of anesthetized female mice, comparing anterior and posterior hypothalamic coronal sections, voxelized t-statistic maps, raw c-Fos expression, and nuclear density maps between male and female mice after isoflurane exposure, with significant differences in c-Fos cell densities across eight hypothalamic sites.
  • Davoudian et al. (2023) ACS Chemical Neuroscience
  • Lal et al. (2023) Nature
  • Yao et al. (2022) Neuron: Figure 1: Figure 1. Activity-dependent genetic labeling of NST barosensitive neurons.
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