Track the Status of Individual Cells Across Tissues

Use Case: Pinpoint the spatial location of specific cell types within tissues and organoids

Detect rare events: Combine volumetric imaging with cell-state dependent reporters to easily find rare cell activation states like the integrated stress response that are sparsely distributed throughout large tissues.

Map cell activity: Use the immediate early gene marker cFos to identify activation of cells in response to behavior, treatments, and experimental interventions.

Identify activated cells: Use changes in cell morphology to identify activated cells like reactive astrocytes due to injury or disease in the central nervous system.

For additional publications supporting this use case refer to:

Helseth et al. Science 372(6540):eabe1931 (2021) – See Figure 1E

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