Over 190 million people have now been infected with the novel coronavirus SARS-CoV-2 in the ongoing coronavirus disease (COVID-19) pandemic with a total number of deaths passing 4.1 million worldwide. Multiple organs are affected by COVID-19, however, the lungs are the main site of disease....

Check out these upcoming publications utilizing LifeCanvas products and technologies! Our tissue processing methods and devices are utilized around the world to further medical and biological research, facilitating new discoveries and improving lives. The articles below are posted prior to peer-review in open-access medRxiv and...

As explained in several of our blogs, delipidation is a critical step in the tissue clearing process. Some form of lipid removal is present in almost all of the most popular clearing techniques, including CLARITY, iDISCO, SHIELD, and CUBIC. In the case of SHIELD and...

Recent advances in the tissue clearing field have unlocked the visualization of biology throughout whole organs. Tissue processing methods that render tissue optically transparent can be combined with methods that enable the tissue-wide penetration of molecular probes such as antibodies. However, many of these techniques...

Breathtaking progress in life sciences has brought us innovations such as high-throughput and individually-affordable genomic sequencing as well as next-generation flow cytometry that can phenotype dissociated cells for their expression of dozens of markers simultaneously. The development of cutting-edge technology solutions with standardized workflows has...

Histological analysis has classically been performed on thin tissue sections so that fine-scale features such as individual neuronal cell bodies and cellular processes can be resolved using light microscopy. This tissue-thickness limitation is due to two primary mechanisms: (#1) contamination of the focal plane by...