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Mouse Brain: Mouse GFAP

Mouse GFAP staining in a whole mouse brain (40 µm max intensity projection).

Zoom in of hippocampus (left) and cerebellum (right) below.

Protocol

1. Standard SHIELD protocol.

2. Passive delipidation with Clear+ Delipidation Buffer.

3. 2 days blocking with Blocking Buffer at 37°C.

4. Radiant Labeling in SmartBatch+ using 10 µg Mouse anti-GFAP antibody in the Single Sample Staining Cup.

5. Secondary Labeling with 20 µg Donkey anti-Mouse Alexa 555+ in SmartBatch+.

6. EasyIndex index matching and mounting.

7. Imaged on SmartSPIM with 3.6X objective.