SmartClear II Pro

Note: SmartClear is now a legacy device and our inventory is limited. Check out SmartBatch+ for active batch clearing and labeling functionality in one device.

Tissue Clearing - Highlighted pipeline icon

Active tissue clearing made easy

SmartClear II Pro is ready-to-use, an order of magnitude faster than passive clearing, and provides optimal imaging and staining quality. Our SmartClear system effectively delipidates for best antibody diffusion and minimal light scatter, and ensures maximum preservation of fluorescent protein signals with optimized buffers that maintain pH.

Patent-pending nanoporous membranes prevent common issues including tissue damage, contamination, browning, black precipitates, and deformation.

SmartClear II Pro
Sample Holders

Efficient and cost-effective

SmartClear II Pro can clear 4 whole mouse brains, 2 rat brains, or similarly sized samples simultaneously. Its customizable larger chamber enables clearing of various sample types and sizes to suit your needs.

Our Clear+ tissue clearing buffer set maximizes optical transparency, minimizes clearing time, and lasts ~10 days without losing efficacy. Plus, there is no tissue shrinkage or expansion!

Highly compatible

SmartClear II Pro works with many tissue preservation techniques which avoid the loss of endogenous fluorescence and tissue shrinkage present in organic solvent-based methods. The SmartClear system is compatible with:

Uniform, rapid intact tissue staining can then be achieved SmartBatch+.

Set up your device

Recent publications citing SmartClear

Neural networks of the mouse visceromotor cortex

Houri Hintiryan, Muye Zhu, Pingping Zhao, Mingmin Zhang, Joshua Barry, Sumit Nanda, Mitchell Rudd, Angela Wong, Samara Miller, Lin Gou, Jinxing Wei, Brian Zingg, Jiandong Sun, Adriana Gutierrez, Hyun-Seung Mun, Yeji E. Han, Ian Bowman, Luis Garcia, Darrick Lo, Tyler Boesen, Chunru Cao, Qiuying Zhao, Nicholas N. Foster, Keivan Moradi, Seita Yamashita, Christian Estrada, Aishwarya Dev, Jennifer Gonzalez, Hanpeng Xu, Gavin Yang, Chang Sin Park, X. William Yang, Michael S. Levine, Li I. Zhang, Paul Micevych, Carlos Cepeda, Peyman Golshani, Weizhe Hong & Hong-Wei Dong

Journal:
Nature
Publication Date:
Research Area:
Neural Circuits
Tissue Species:
Mouse
Tissue Type:
Brain
Products Cited:
SHIELD, EasyIndex, SmartClear, SmartLabel, SmartSPIM
Brain-wide connectivity and novelty response of the dorsal endopiriform nucleus in mice

Steffy B Manjila, Seoyoung Son, Deniz Parmaksiz, Hannah Kline, Rebecca Betty, Yuan-ting Wu, Hyun-Jae Pi, Donghui Shin, Josephine K Liwang, Fae N Kronman, Ingvild E Bjerke, Kyle McGovern, Justin Silverman, Anirban Paul, Yongsoo Kim

Journal:
Cell Reports
Publication Date:
Research Area:
Neural Circuits
Tissue Species:
Mouse
Tissue Type:
Brain
Products Cited:
SmartClear, SmartLabel, SmartSPIM
Opioid-driven disruption of the septum reveals a role for neurotensin-expressing neurons in withdrawal

Rhiana C. Simon, Weston T. Fleming, Brandy A. Briones, Marta Trzeciak, Pranav Senthilkumar, Kentaro K. Ishii, Madelyn M. Hjort, Madison M. Martin, Koichi Hashikawa, Andrea D. Sanders, Sam A. Golden, Garret D. Stuber

Journal:
Neuron
Publication Date:
Research Area:
Neural Circuits
Tissue Type:
Brain
Products Cited:
SHIELD, SmartClear, SmartSPIM