Plot the Spatial Distribution of Proteins and Post-Translational Modifications

Protein Mapping

Use Case: Plot the Spatial Distribution of Proteins and Post-Translational Modifications

Profile endogenous protein expression patterns: Measure protein levels across regions to facilitate comparison of baseline protein expression patterns to experimental groups.
Visualize genetically expressed proteins: Label genetically expressed, epitope-tagged, wildtype and mutant proteins to visualize their cellular and subcellular distribution in whole tissues and their association with other biological structures.
Map post-translational modifications: Determine where the regulation of protein activity, localization, and interaction with other biological molecules is taking place within cells and tissues by monitoring protein post-translational modifications.

(Ref 1) Figure 2: Whole-brain imaging reveals the topographical distribution of Sumo paralogs. (A) Schematic of brain clearing and light sheet microscopy for whole brain imaging. Heatmaps and bar plots of Sumo2 (B,C) and Sumo1 (D,E) signal intensity across brain regions. Article distributed under the terms of the Creative Commons CC-BY license.

For additional publications supporting this use case refer to:

  1. Suk et al. iScience 26(4):106350 (2023) – Figure 2, Supplementary Figure S2, Video S1, S2
  2. Geertsma et al. NPJ Parkinson’s Disease 10, 65 (2024) – Figure 1d, Supplementary Figure 2
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