Circuit Mapping | Phenotype Peripheral Nerve Innervation Patterns

Circuit Mapping

Use Case: Phenotype Peripheral Nerve Innervation Patterns

  • Connect brain and periphery: Discover how different molecularly-defined neurons come together to send signals from the brain to organs and from the organs back to brain by tracing the neuronal connections between them using viral, transgenic, or immunolabeling strategies.
  • Track disease progression: Follow the worsening or improvement of neurodegeneration in different models of motor neuron disease by evaluating the loss of maintenance of innervation.
  • Capture morphological diversity: Categorize sensory and motor nerve endings and infer their neurophysiological function based on the pattern or innervation with the organs they supply.

(Ref 3) Supplementary video 1: 3D light-sheet microscopy video of a cleared heart showing NPY2R vagal innervation. 

 Article licensed under the terms of the http://creativecommons.org/licenses/by/4.0/.

For additional publications supporting this use case refer to:

  1. Lorenz et al. Journal of Bone and Mineral Research 36(5):1012-1025 (2021) – Figure 5a-5c
  2. Nature, Wang et al. Nature 609, 569–574 (2022) – Figure 1, Extended Data Figure 1a, 1c, Supplementary Video 1
  3. Lovelace et al. Nature 623, 387–396 (2023) – Figure 1a, 1d, 1e, 1g, 1i, 1j, Extended Figure 1, Supplementary Video 1
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