SmartLabel

Note: SmartLabel is now a legacy device and our inventory is limited. Check out SmartBatch+ for active batch clearing and labeling functionality in one device.

Tissue labeling - Highlighted pipeline icon

Rapid and strikingly uniform immunostaining

SmartLabel labels large intact samples an order of magnitude faster than passive techniques (≤ 24 hours vs. weeks to months). Our technology achieves unparalleled uniformity of signal intensity from surface to core, and our patent-pending nanoporous membranes eliminate tissue contamination and probe loss.

SmartLabel

Easy and cost-effective

Simply load the buffers, your sample, and probes. Our system can simultaneously perform 2 distinct experiments thanks to its dual chamber design. 

SmartLabel uses as little as 3 µg of antibody to label tissues the size of a whole mouse brain and prevents antibody depletion caused by excessive binding to superficial tissue sites.

Highly compatible

SmartLabel works with many tissue preservation techniques which avoid the loss of endogenous fluorescence and tissue shrinkage present in organic solvent-based clearing methods. SmartLabel is compatible with:

Rapid tissue clearing can be achieved with SmartBatch+ or SmartClear II Pro.

Set up your device

Recent publications citing SmartLabel

Brain-wide connectivity and novelty response of the dorsal endopiriform nucleus in mice

Steffy B Manjila, Seoyoung Son, Deniz Parmaksiz, Hannah Kline, Rebecca Betty, Yuan-ting Wu, Hyun-Jae Pi, Donghui Shin, Josephine K Liwang, Fae N Kronman, Ingvild E Bjerke, Kyle McGovern, Justin Silverman, Anirban Paul, Yongsoo Kim

Journal:
Cell Reports
Publication Date:
Research Area:
Neural Circuits
Tissue Species:
Mouse
Tissue Type:
Brain
Products Cited:
SmartClear, SmartLabel, SmartSPIM
Hippocampal Engrams Generate Variable Behavioral Responses and Brain-Wide Network States

Kaitlyn E. Dorst, Ryan A. Senne, Anh H. Diep, Antje R. de Boer, Rebecca L. Suthard, Heloise Leblanc, Evan A. Ruesch, Angela Y. Pyo, Sara Skelton, Lucas C. Carstensen, Samantha Malmberg, Olivia P. McKissick, John H. Bladon and Steve Ramirez.

Journal:
The Journal of Neuroscience
Publication Date:
Tissue Type:
Brain
Products Cited:
SHIELD, EasyIndex, SmartClear, SmartLabel, SmartSPIM, CRO Services
A Light sheet fluorescence microscopy and machine learning-based approach to investigate drug and biomarker distribution in whole organs and tumors

Niyanta Kumar, Petr Hrobar, Martin Vagenknecht, Jindrich Soukup, Nadia Patterson, Peter Bloomingdale, Tomoko Freshwater, Sophia Bardehle, Roman Peter, Ruban Mangadu, Cinthia V Pastuskovas, Chiswili Yves Chabu, Mark T. Cancilla

Journal:
bioRxiv
Publication Date:
Research Area:
Neurodegeneration, Cancer, Vasculature, Methods
Tissue Species:
Mouse
Tissue Type:
Brain, Tumor
Products Cited:
SHIELD, EasyIndex, SmartClear, SmartLabel, SmartSPIM, SmartAnalytics, CRO Services