SmartLabel

Note: SmartLabel is now a legacy device and our inventory is limited. Check out SmartBatch+ for active batch clearing and labeling functionality in one device.

Tissue labeling - Highlighted pipeline icon

Rapid and strikingly uniform immunostaining

SmartLabel labels large intact samples an order of magnitude faster than passive techniques (≤ 24 hours vs. weeks to months). Our technology achieves unparalleled uniformity of signal intensity from surface to core, and our patent-pending nanoporous membranes eliminate tissue contamination and probe loss.

SmartLabel

Easy and cost-effective

Simply load the buffers, your sample, and probes. Our system can simultaneously perform 2 distinct experiments thanks to its dual chamber design. 

SmartLabel uses as little as 3 µg of antibody to label tissues the size of a whole mouse brain and prevents antibody depletion caused by excessive binding to superficial tissue sites.

Highly compatible

SmartLabel works with many tissue preservation techniques which avoid the loss of endogenous fluorescence and tissue shrinkage present in organic solvent-based clearing methods. SmartLabel is compatible with:

Rapid tissue clearing can be achieved with SmartBatch+ or SmartClear II Pro.

Set up your device

Recent publications citing SmartLabel

Neural networks of the mouse visceromotor cortex

Houri Hintiryan, Muye Zhu, Pingping Zhao, Mingmin Zhang, Joshua Barry, Sumit Nanda, Mitchell Rudd, Angela Wong, Samara Miller, Lin Gou, Jinxing Wei, Brian Zingg, Jiandong Sun, Adriana Gutierrez, Hyun-Seung Mun, Yeji E. Han, Ian Bowman, Luis Garcia, Darrick Lo, Tyler Boesen, Chunru Cao, Qiuying Zhao, Nicholas N. Foster, Keivan Moradi, Seita Yamashita, Christian Estrada, Aishwarya Dev, Jennifer Gonzalez, Hanpeng Xu, Gavin Yang, Chang Sin Park, X. William Yang, Michael S. Levine, Li I. Zhang, Paul Micevych, Carlos Cepeda, Peyman Golshani, Weizhe Hong & Hong-Wei Dong

Journal:
Nature
Publication Date:
Research Area:
Neural Circuits
Tissue Species:
Mouse
Tissue Type:
Brain
Products Cited:
SHIELD, EasyIndex, SmartClear, SmartLabel, SmartSPIM
Brain-wide connectivity and novelty response of the dorsal endopiriform nucleus in mice

Steffy B Manjila, Seoyoung Son, Deniz Parmaksiz, Hannah Kline, Rebecca Betty, Yuan-ting Wu, Hyun-Jae Pi, Donghui Shin, Josephine K Liwang, Fae N Kronman, Ingvild E Bjerke, Kyle McGovern, Justin Silverman, Anirban Paul, Yongsoo Kim

Journal:
Cell Reports
Publication Date:
Research Area:
Neural Circuits
Tissue Species:
Mouse
Tissue Type:
Brain
Products Cited:
SmartClear, SmartLabel, SmartSPIM
Wireless In Situ Catalytic Electron Signaling-Mediated Transcriptomic Reprogramming for Neuron Regeneration via Adaptable Antennas

Hoi Man Iao, Chih-Ying Chen, Ya-Hui Lin, Wan-Chi Pan, Chun-Yi Liang, Hsiu-Ching Liu, Lo-Jei Ching, Pei-Yu Weng, Min-Ren Chiang, Ru-Siou Hsu, Tsu-Chin Chou, I-Chi Lee, Lun-De Liao, Li-An Chu, Shih-Hwa Chiou, Shang-Hsiu Hu

Journal:
Advanced Science
Publication Date:
Research Area:
Stroke & Brain Injury, Neural Interfaces
Tissue Species:
Mouse
Tissue Type:
Brain
Products Cited:
SHIELD, SmartClear, SmartLabel, SmartSPIM