Quantitate amyloid, synuclein, and tau deposits

Use Case: Quantitate amyloid, synuclein, and tau deposits

Detect neuropathologies across brain regions: Examine the extent of naturally occurring pathologies in human brains afflicted with neurodegenerative disease.

Follow neuropathology progression: Study the biology of protein aggregate formation and spread across neural circuits in different animal models of neurodegenerative disease.

Monitor therapeutic efficacy: Measure the effect of therapeutic interventions on protein aggregate load in discrete regions of the brain for the treatment of various neurodegenerative diseases.

Figure 3 (Ref 5): (a) Tissue from donor AD 6 shows areas with leptomeningeal CAA pathology, (b) tissue from donor AD 5 shows a rare CAA-positive vessel, (c) frequent CAA-positive vessels were observed in donor AD 1, (d) closeup of the dashed box in b, (e) closeup of the dashed box in d.

Movie S1 (Ref 5): CAA pathology and tau accumulation. Article licensed under Creative Commons Attribution 4.0 International License.

For additional publications supporting this use case refer to:

Martorell et al. Cell 177(2), 256-271 (2019) – See Supplementary Figure 4g
Soula et al. Nature Neuroscience 26, 570–578 (2023) – Extended Data Figure 1
Chen et al. PNAS 120 (21) e2220684120 (2023) – See Figure 4b, Movie S1-2
Jiang et al. Frontiers in Neuroscience 20:18:1372297 (2024) – See Video 1-3
Hoglund et al. Acta Neuropathol 147, 101 (2024) – See Figure 3a-3g, Supplementary Movie 1

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