Virus Mapping | Profile infectious viruses throughout tissues

Virus Mapping

Use Case: Profile infectious viruses in tissues

Track virus spread: Maintenance of organ integrity and organ systems en bloc makes it possible to follow systemic virus transmission.
Calculate viral load: Count virus particles in whole organs of infected animals to determine if therapeutic administration is stopping the virus from growing.
Visualize bodily changes: Ascertain the viral impact on the anatomy and physiology of cells, tissues, organ systems as well as the ensuing immune response.

3D rendering of a HYBRiD-cleared chest from a SARS-CoV-2-infected K18-hACE2 transgenic mouse. Blue is the autofluorescence signal used to outline the organs. Red is the anti-SARS-CoV NP AlexaFluor 647 signal. In-plane resolution, 1.75 µm/pixel; z-step size, 4 µm. Image volume: 19 mm × 19 mm × 13 mm.

For additional publications supporting this use case refer to:

  1. Nudell et al. Nature Methods 19,479-485 (2022) – See figure 3-5, Extended Data Figure 3-6, Supplementary Video 1-4
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