Neuropathology Mapping | Quantitate amyloid, synuclein, and tau deposits

Use Case: Quantitate amyloid, synuclein, and tau deposits

Detect neuropathologies across brain regions: Examine the extent of naturally occurring pathologies in human brains afflicted with neurodegenerative disease.

Follow neuropathology progression: Study the biology of protein aggregate formation and spread across neural circuits in different animal models of neurodegenerative disease.

Monitor therapeutic efficacy: Measure the effect of therapeutic interventions on protein aggregate load in discrete regions of the brain for the treatment of various neurodegenerative diseases.

CAA pathology and tau accumulation. (a) Tissue from donor AD 6 shows areas with leptomeningeal CAA pathology, (b) tissue from donor AD 5 shows a rare CAA-positive vessel, (c) frequent CAA-positive vessels were observed in donor AD 1, (d) closeup of the dashed box in b, (e) closeup of the dashed box in d.

Figure 3, extracted from Hoglund, Z., Ruiz-Uribe, N., del Sastre, E. et al. Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer’s disease. Acta Neuropathol 147, 101 (2024). https://doi.org/10.1007/s00401-024-02751-9. This article is licensed under a Creative Commons Attribution 4.0 International License.

For additional publications supporting this use case refer to:

Hoglund et al. Acta Neuropathol 147, 101 (2024) – See Figure 3a-3g, Supplementary Movie 1
Jiang et al. Frontiers in Neuroscience 20:18:1372297 (2024) – See Video 1-3
Chen et al. PNAS 120 (21) e2220684120 (2023) – See Figure 4b, Movie S1-2
Soula et al. Nature Neuroscience 26, 570–578 (2023) – Extended Data Figure 1
Martorell et al. Cell 177(2), 256-271 (2019) – See Supplementary Figure 4g

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