Neurological Disorders

Alzheimer’s disease pathology in human cortical tissue

Phospho-tau staining of human frontal cortex
Phospho-tau labeling of human frontal cortex tissue isolated post-mortem from a clinical patient with advanced Alzheimer’s disease demonstrates widespread labeling of this pathological hallmark. Tissue courtesy of Kymry Jones and Prof. Carol Miller, USC.

Using histological techniques to visualize the distribution of phosphorylated tau protein, a hallmark of Alzheimer’s disease, can help researchers better understand disease mechanisms and assess the level of pathology in post-mortem tissue. LifeCanvas’ methods and technologies are fully compatible with human tissue samples, providing a clearer window into human clinical specimen analysis and disease diagnosis.

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Right: 3D volume rendering of the left cerebral hemisphere of a mouse model of Alzheimer’s disease, with labeling of amyloid-beta plaques by fluorescent reporters (bright spots) performed in < 2 days using eFLASH. (Martorell et al. 2019)