Prof. Li-Huei Tsai’s lab at MIT is focused on uncovering the cellular and circuit-level mechanisms that underlie Alzheimer’s disease, the devastating neurological disorder that degrades the brain’s learning and memory systems. In a 2016 paper in Nature (Iaccarino et al.), the lab reported the surprising discovery that by simply entraining the activity of cortical networks… Continue reading Whole brain molecular labeling & imaging techniques shed new light on Alzheimer’s Disease
Breathtaking progress in life sciences has brought us innovations such as high-throughput and individually-affordable genomic sequencing as well as next-generation flow cytometry that can phenotype dissociated cells for their expression of dozens of markers simultaneously. The development of cutting-edge technology solutions with standardized workflows has led to increased efficiency and reliability for these and other… Continue reading Tissue processing in the 21st century
Take advantage of whole-sample methods to: Reduce processing work and view samples in multiple anatomical planes Localize regions of interest more confidently by visualizing organ-sized datasets that provide greater context Acquire data on all sample regions in parallel, facilitating analyses that are more quantitatively robust Explore fertile ground where novel and unexpected discoveries can take… Continue reading Why use intact samples for your research?