Alzheimer's Disease

Alzheimer’s Disease Pathology in Human Cortical Tissue

Using histological techniques to visualize the distribution of phosphorylated tau protein, a hallmark of Alzheimer’s disease, can help researchers better understand disease mechanisms and assess the level of pathology in post-mortem tissue. LifeCanvas’s methods and technologies are fully compatible with human tissue samples, thus providing an unparalleled window into human clinical specimen analysis and disease diagnosis.

Phospho-tau labeling of human frontal cortex tissue isolated post-mortem from a clinical patient with advanced Alzheimer’s disease demonstrates widespread labeling of this pathological hallmark. Tissue courtesy of Kymry Jones and Prof. Carol Miller, USC.

Phospho-tau staining of human frontal cortex

For more AD applications, check out this blog post describing the groundbreaking research on Alzheimer’s Disease by the Tsai lab at MIT:

Whole Brain Molecular Labeling & Imaging Techniques Shed New Light on Alzheimer’s Disease

Researchers were able to visualize and analyze plaque development in Alzheimer’s Disease model mice using LifeCanvas devices and reagents, including SHIELD and SmartClear II Pro